There are three heads Aya has to deal with, each with its own HP but the same set of attacks. The first is a near-unavoidable giant shock wave that cuts Aya's HP in half, the second a lunging bite when Aya is in range, and finally an energy blast that will stretch across most the room. Aya will mostly be on her guard the entire battle, the best time to attack when Sheeva goes to heal one of her heads for 100 HP each or just after avoiding Sheeva's attacks. Considering how each head has its own HP, it is probably best to focus on killing one of the heads on the side first, then kill the other side, and finally the center head.
- Kerberos is a reference to the three-headed dog Cerberus from Greek mythology. Kerberos is another way of translating its name.
- Kerberos' transformation seems to have been inspired by Kennel-Thing from The Thing. Kennel-Thing's head split open and it also grew strange appendages.
|Aya Brea - Daniel Dollis - Kunihiko Maeda - Melissa Pearce - Mitochondria Eve|
Maya Brea - Ben Dollis - Lorraine Dollis - Hans Klamp - Douglas Baker - Torres Owens - Wayne Garcia
|Armadillo - Bacterium - Bat - Bear - Cat - Chameleon - Crow - Dogman - Flyman - Frog - Mixedman - Mole - Monkey - Parrot - Plant - Pterodactyl - Rat - Ratman - Spider - Scorpion - Squirrel - Snake - Treasurebox - Troodon|
|Alligator - Bee - Centipede - Cockroach - Crab - Eve - Giantworm - Kerberos - Spiderwoman - Triceratops - Truebred Eve - T-Rex - Ultimate Being|
|American Museum of Natural History - Carnegie Hall - Central Park - Chinatown - Chrysler Building - N.Y.P.D. - Sewers - Soho - St. Francis Hospital - Subway - Warehouse|
|Weapons - Armor - Items - Gameplay - Soundtrack - Remixes Soundtrack|