Soho is a district of New York City which Aya Brea, Daniel Dollis and Kunihiko Maeda explore after Aya's third fight with Eve, at the end of Day Two. Maeda finds Aya and brings her back to a small apartment. Aya wakes up and meets Maeda who is watching the TV. Daniel arrives and Maeda explains about what is happening to the city. At the beginning of Day Three, the group gathers supplies from the nearby area before go to the American Museum of Natural History. After the events that transpire there, they find out that the Police Precinct is being attacked by NMCs.
|Aya Brea - Daniel Dollis - Kunihiko Maeda - Melissa Pearce - Mitochondria Eve|
Maya Brea - Ben Dollis - Lorraine Dollis - Hans Klamp - Douglas Baker - Torres Owens - Wayne Garcia
|Armadillo - Bacterium - Bat - Bear - Cat - Centipede - Chameleon - Crow - Dogman - Flyman - Frog - Mixedman - Mole - Monkey - Parrot - Plant - Pterodactyl - Rat - Ratman - Spider - Scorpion - Squirrel - Snake - Treasurebox - Troodon|
|Alligator - Bee - Cockroach - Crab - Eve - Giantworm - Kerberos - Spiderwoman - Triceratops - Truebred Eve - T-Rex - Ultimate Being|
|American Museum of Natural History - Carnegie Hall - Central Park - Chinatown - Chrysler Building - N.Y.P.D. - Sewers - Soho - St. Francis Hospital - Subway - Warehouse|
|Weapons - Armor - Items - Gameplay - Soundtrack - Remixes Soundtrack|